Ghana will travel to South Africa to take on the Bafana Bafana in the second match of the 2022 FIFA World Cup qualifications on Monday 6 September in Johannesburg.
The Black Stars will be looking to making it two wins out of two at the FNB Stadium.
Ghana and South Africa have faced themselves 12 times in all competitions since their first meeting on 26 November 1994.
The Black Stars have managed 4 wins over the Bafana Bafana whereas the latter also have 4 wins.
Six of the meetings have ended in a stalemate.
South Africa have not beaten the Black Stars in any match since 11 August 2010, across that period Ghana have two wins and three days.