Ghana head coach Milovan Rajevac has named his team to play in the two World Cup qualifiers this month giving youngsters Afena-Gyan and Edmund Addo their maiden call-ups.
The Serbian coach has selected 28 players for the vital matches with Ethiopia as well as South Africa on November 11 and 14.
Famous names like Andre Ayew, Jordan Ayew, and Thomas Partey were all named in the squad.
There is also an opportunity for the well-known player Richmond Bokye-Yiadom.
Ghana will be heading into South Africa to play Ethiopia before concluding the group with a clash against Bafana Bafana at the Cape Coast sports stadium.
Below is the squad for the two matches:
Goalkeepers: Joseph Wollacott (Swindon Town), Lawrence Ati-Zigi (St.Gallen), Manaf Nurudeen (Eupen), Richard Attah (Hearts of Oak)
Defenders: Andy Yiadom (Reading FC), Philemon Baffour (Dreams FC), Baba Abdul Rahman (Reading FC), Gideon Mensah (Girondins Bordeaux), Daniel Amartey (Leicester City), Alexander Djiku (Strasbourg), Joseph Aidoo (Celta Vigo), Jonathan Mensah (Columbus Crew), Ismail Abdul Ganiyu (Asante Kotoko)
Midfielders: Baba Idrissu (Real Mallorca), Thomas Partey (Arsenal FC), Mubarak Wakaso (Shenzhen F.C), Edmund Addo (Sheriff Tiraspol), Mohammed Kudus (Ajax Amsterdam), Daniel Kofi Kyere (FC St. Pauli)
Wingers: Andre Ayew (Al Sadd), Jordan Ayew (Crystal Palace), Abdul Fatawu Issahaku (Dreams FC), Kamal Deen Sulemana (Rennes), Samuel Owusu (Al Fayha)
Strikers: Richmond Boakye-Yiadom (Beitar Jerusalem), Benjamin Tetteh (Yeni Malatyaspor), Felix Afena Gyan (AS Roma), Caleb Ekuban (Genoa)