The substantive captain of the Black Stars Andre Ayew will miss the second-leg match against Angola in Luanda after sustaining an injury.
Thomas Partey will therefore step up to perform the captaincy duties in his absence.
Andre Ayew is reported to have picked up a knock during warm-up in the first leg of the AFCON qualifier encounter at the Baba Yara Sports Stadium.
He did not play any part in Ghana’s narrow 1-0 over Angola last Thursday. Partey is expected to assume the leadership role of the team when Ghana plays Angola on Monday 27 March.
Thomas Partey was integral in the Black Star’s first-leg win over the Palancas Negras.
The Black Stars will earn qualification to the 2023 AFCON in Ivory Coast should they beat Angola in Luanda.
Ghana sits top of Group E with seven points after three games, three points clear of second-place Angola while the Central African Republic sits third with four points.